FOS like 2, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3798]
Entrez Summary
#!usr/local/bin/perl
?>
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and
FOSL2. These genes encode leucine zipper proteins that can dimerize with
proteins of the JUN family, thereby forming the transcription factor complex
AP-1. As such, the FOS proteins have been implicated as regulators of cell
proliferation, differentiation, and transformation. [provided by RefSeq, Jul
2014]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8954781
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF