Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description: | T-box 21 [Source:HGNC Symbol;Acc:HGNC:11599] | |||
Entrez Summary | #!usr/local/bin/perl ?> This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008] | |||
Ensembl ID: | ENSG00000073861 | |||
External Link: | CisBP | |||
Interpro | IPR001699; IPR008967; IPR018186; ; | |||
Protein Domain: | ENSP00000177694 | |||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:10761931 15662016 16275766 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10761931 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |