TF Info Page for TP63 (p53)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: tumor protein p63 [Source:HGNC Symbol;Acc:HGNC:15979]
Entrez Summary This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
Ensembl ID: ENSG00000073282
External Link: CisBP
Interpro IPR001660; IPR002117; IPR008967; IPR010991; IPR011510; IPR011615; IPR013761; ;
Protein Domain: ENSP00000264731
Protein Domain: ENSP00000317510
Protein Domain: ENSP00000346614
Protein Domain: ENSP00000376254
Protein Domain: ENSP00000376256
Protein Domain: ENSP00000407144
Protein Domain: ENSP00000392488
Protein Domain: ENSP00000387839
Domain:
Protein: ENSP00000264731DBD: p53Other: P53_tetramer, SAM_2
Protein: ENSP00000317510DBD: p53Other: P53_tetramer
Protein: ENSP00000346614DBD: p53Other: P53_tetramer, SAM_2
Protein: ENSP00000376254DBD: p53Other: P53_tetramer
Protein: ENSP00000376256DBD: p53Other: P53_tetramer
Protein: ENSP00000407144DBD: p53Other: P53_tetramer
Protein: ENSP00000392488DBD: p53Other: P53_tetramer
Protein: ENSP00000387839DBD: p53Other: P53_tetramer, SAM_2

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate__Transactivation_
PMIDS:9774969
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
SELEXJASPARDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
ChIP-seqhmCHIPInferred - TP73 (85% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - TP73 (85% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - TP73 (85% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TP73 (85% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TP73 (85% AA Identity, Homo sapiens)

Structure

Structure PDB 3QYM

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution