The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

tumor protein p63 [Source:HGNC Symbol;Acc:HGNC:15979]

Entrez Summary

Ensembl ID:

ENSG00000073282

External Link:

CisBP

Interpro

IPR001660; IPR002117; IPR008967; IPR010991; IPR011510; IPR011615; IPR013761; ;

Protein Domain:

ENSP00000264731

Protein Domain:

ENSP00000317510

Protein Domain:

ENSP00000346614

Protein Domain:

ENSP00000376254

Protein Domain:

ENSP00000376256

Protein Domain:

ENSP00000407144

Protein Domain:

ENSP00000392488

Protein Domain:

ENSP00000387839

Domain:

Protein: ENSP00000264731	DBD: p53	Other: P53_tetramer, SAM_2
Protein: ENSP00000317510	DBD: p53	Other: P53_tetramer
Protein: ENSP00000346614	DBD: p53	Other: P53_tetramer, SAM_2
Protein: ENSP00000376254	DBD: p53	Other: P53_tetramer
Protein: ENSP00000376256	DBD: p53	Other: P53_tetramer
Protein: ENSP00000407144	DBD: p53	Other: P53_tetramer
Protein: ENSP00000392488	DBD: p53	Other: P53_tetramer
Protein: ENSP00000387839	DBD: p53	Other: P53_tetramer, SAM_2

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene Candidate__Transactivation_ PMIDS:9774969
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
SELEX	JASPAR		Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
ChIP-seq	hmCHIP		Inferred - TP73 (85% AA Identity, Homo sapiens)
ChIP-seq	hmCHIP		Inferred - TP73 (85% AA Identity, Homo sapiens)
ChIP-seq	hmCHIP		Inferred - TP73 (85% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - TP73 (85% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - TP73 (85% AA Identity, Homo sapiens)

Structure

Structure	PDB	3QYM

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 359, "endStyle": "curved", "aliStart": 164, "text": "P53", "colour": "#228B22", "aliEnd": 358, "start": 163, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 359, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 164, "scoreName": "E-value", "accession": "PF00870.16", "start": 163, "score": 2.3999999999999995e-110, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 358}}, {"startStyle": "straight", "end": 431, "endStyle": "straight", "aliStart": 391, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 430, "start": 391, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 431, "description": NaN, "database": "PfamA", "aliStart": 391, "scoreName": "E-value", "accession": "PF07710.9", "start": 391, "score": 6.7e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 430}}, {"startStyle": "straight", "end": 605, "endStyle": "straight", "aliStart": 542, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 603, "start": 541, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 605, "description": NaN, "database": "PfamA", "aliStart": 542, "scoreName": "E-value", "accession": "PF07647.15", "start": 541, "score": 2.7000000000000005e-10, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 603}}], "length": 681}

{"regions": [{"startStyle": "curved", "end": 359, "endStyle": "curved", "aliStart": 164, "text": "P53", "colour": "#228B22", "aliEnd": 358, "start": 163, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 359, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 164, "scoreName": "E-value", "accession": "PF00870.16", "start": 163, "score": 1.2999999999999997e-110, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 358}}, {"startStyle": "straight", "end": 431, "endStyle": "straight", "aliStart": 391, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 430, "start": 391, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 431, "description": NaN, "database": "PfamA", "aliStart": 391, "scoreName": "E-value", "accession": "PF07710.9", "start": 391, "score": 4e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 430}}], "length": 511}

{"regions": [{"startStyle": "curved", "end": 265, "endStyle": "curved", "aliStart": 70, "text": "P53", "colour": "#228B22", "aliEnd": 264, "start": 69, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 265, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 70, "scoreName": "E-value", "accession": "PF00870.16", "start": 69, "score": 1.3999999999999994e-110, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 264}}, {"startStyle": "straight", "end": 337, "endStyle": "straight", "aliStart": 297, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 336, "start": 297, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 337, "description": NaN, "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF07710.9", "start": 297, "score": 5.3e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 336}}, {"startStyle": "straight", "end": 511, "endStyle": "straight", "aliStart": 448, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 509, "start": 447, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 511, "description": NaN, "database": "PfamA", "aliStart": 448, "scoreName": "E-value", "accession": "PF07647.15", "start": 447, "score": 2.2000000000000002e-10, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 509}}], "length": 587}

{"regions": [{"startStyle": "curved", "end": 265, "endStyle": "curved", "aliStart": 70, "text": "P53", "colour": "#228B22", "aliEnd": 264, "start": 69, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 265, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 70, "scoreName": "E-value", "accession": "PF00870.16", "start": 69, "score": 5.699999999999999e-111, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 264}}, {"startStyle": "straight", "end": 337, "endStyle": "straight", "aliStart": 297, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 336, "start": 297, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 337, "description": NaN, "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF07710.9", "start": 297, "score": 2.8e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 336}}], "length": 417}

{"regions": [{"startStyle": "curved", "end": 265, "endStyle": "curved", "aliStart": 70, "text": "P53", "colour": "#228B22", "aliEnd": 264, "start": 69, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 265, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 70, "scoreName": "E-value", "accession": "PF00870.16", "start": 69, "score": 7.799999999999999e-111, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 264}}, {"startStyle": "straight", "end": 337, "endStyle": "straight", "aliStart": 297, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 336, "start": 297, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 337, "description": NaN, "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF07710.9", "start": 297, "score": 3.5e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 336}}], "length": 462}

{"regions": [{"startStyle": "curved", "end": 359, "endStyle": "curved", "aliStart": 164, "text": "P53", "colour": "#228B22", "aliEnd": 358, "start": 163, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 359, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 164, "scoreName": "E-value", "accession": "PF00870.16", "start": 163, "score": 1.4999999999999996e-110, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 358}}, {"startStyle": "straight", "end": 431, "endStyle": "straight", "aliStart": 391, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 430, "start": 391, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 431, "description": NaN, "database": "PfamA", "aliStart": 391, "scoreName": "E-value", "accession": "PF07710.9", "start": 391, "score": 3.7e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 430}}], "length": 488}

{"regions": [{"startStyle": "curved", "end": 265, "endStyle": "curved", "aliStart": 70, "text": "P53", "colour": "#228B22", "aliEnd": 264, "start": 69, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 265, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 70, "scoreName": "E-value", "accession": "PF00870.16", "start": 69, "score": 8.899999999999998e-111, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 264}}, {"startStyle": "straight", "end": 337, "endStyle": "straight", "aliStart": 297, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 336, "start": 297, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 337, "description": NaN, "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF07710.9", "start": 297, "score": 2.5e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 336}}], "length": 394}

{"regions": [{"startStyle": "jagged", "end": 180, "endStyle": "curved", "aliStart": 8, "text": "P53", "colour": "#228B22", "aliEnd": 179, "start": 3, "href": "http://pfam.xfam.org/family/PF00870.16", "type": "pfama", "display": "true", "metadata": {"end": 180, "description": "This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.", "database": "PfamA", "aliStart": 8, "scoreName": "E-value", "accession": "PF00870.16", "start": 3, "score": 1.5999999999999995e-95, "identifier": "P53 DNA-binding domain", "type": "DBD", "aliEnd": 179}}, {"startStyle": "straight", "end": 252, "endStyle": "straight", "aliStart": 212, "text": "P53_tetramer", "colour": "#9999ff", "aliEnd": 251, "start": 212, "href": "http://pfam.xfam.org/family/PF07710.9", "type": "pfama", "display": "true", "metadata": {"end": 252, "description": NaN, "database": "PfamA", "aliStart": 212, "scoreName": "E-value", "accession": "PF07710.9", "start": 212, "score": 4e-19, "identifier": "P53 tetramerisation motif", "type": "DBD", "aliEnd": 251}}, {"startStyle": "straight", "end": 426, "endStyle": "straight", "aliStart": 363, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 424, "start": 362, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 426, "description": NaN, "database": "PfamA", "aliStart": 363, "scoreName": "E-value", "accession": "PF07647.15", "start": 362, "score": 1.8000000000000002e-10, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 424}}], "length": 502}

TF Info Page for TP63 (p53)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution