TF Info Page for NFATC3 (Rel)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: nuclear factor of activated T-cells 3 [Source:HGNC Symbol;Acc:HGNC:7777]
Entrez Summary The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
Ensembl ID: ENSG00000072736
External Link: CisBP
Interpro IPR002909; IPR008366; IPR008967; IPR011539; IPR014756; ;
Protein Domain: ENSP00000331324
Protein Domain: ENSP00000300659
Protein Domain: ENSP00000264008
Protein Domain: ENSP00000456120
Protein Domain: ENSP00000456379
Protein Domain: ENSP00000457441
Domain:
Protein: ENSP00000331324DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000300659DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000264008DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000456120DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000456379DBD: RHDOther: RHD_dimer, TIG
Protein: ENSP00000457441DBD: RHDOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:7650004 7650004 11997392 15173172 7650004 15173172 15173172 16260608
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:15173172 | IMP - PMID:15173172
GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IGI - PMID:23543060
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMZoo_01Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
HT-SELEXJolma2010Inferred - NFATC1 (81% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - NFATC1 (81% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - NFATC1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC1 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC1 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC1 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC1 (81% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC1 (81% AA Identity, Meleagris gallopavo)
PBMZoo_01Inferred - NFATC1 (81% AA Identity, Monodelphis domestica)
PBMZoo_01Inferred - nfatc1 (81% AA Identity, Xenopus tropicalis)
TransfacTransfacLicense requiredInferred - NFATC1 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC1 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC1 (81% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC1 (81% AA Identity, Homo sapiens)
MiscHOMERInferred - NFATC1 (81% AA Identity, Homo sapiens)
PBMTF_EvolutionUnpublished DataInferred - NFATC4 (80% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC4 (80% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC4 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC4 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC4 (80% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC4 (80% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC4 (80% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC4 (80% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC2 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC2 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NFATC2 (78% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC2 (78% AA Identity, Homo sapiens)
COMPILEDJASPARInferred - NFATC2 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC2 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC2 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NFATC2 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NFATC2 (78% AA Identity, Homo sapiens)
PBMZoo_01Inferred - NFATC2 (71% AA Identity, Tetraodon nigroviridis)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution