TF Info Page for MBD3 (MBD)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 3 Low specificity DNA-binding protein | No motif | The MBD domain of MBD3 is thought to be primarily responsible for interaction with HDAC1 and MTA2, members of the NuRD complex (PMID: 12124384). More recently, studies have shown that it retains the ability to bind methylated CpG sites in vitro (PMID: 24307175) with lower affinity than other MBD proteins (e.g., MBD2), but does not distinguish between hydroxymethylated and unmethylated sites. Coupled with in vivo ChIP experiments, it appears that MBD3 binds unmethylated CpG sites in vivo after be |
Description
| Description: | methyl-CpG binding domain protein 3 [Source:HGNC Symbol;Acc:HGNC:6918] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000071655 | |
| External Link: | ||
| Interpro | IPR001739; IPR016177; IPR025884; ; | |
| Protein Domain: | ||
| Protein: ENSP00000156825 | DBD: Methyl-CpG DNA-binding | Other: MBD_C |
| Protein: ENSP00000412302 | DBD: Methyl-CpG DNA-binding | Other: MBD_C |
| Protein: ENSP00000464718 | DBD: Methyl-CpG DNA-binding | Other: MBD_C, MBDa, RasGAP |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
No PMIDS: |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
3a, decent circumstantial evidence for its role as |
| TF has conditional DNA-binding requirements |