TF Info Page for SP100 (SAND)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Gel-shift experiments using human SP100 have shown binding to specific TTCG half sites (PMID: 11427895).


Description: SP100 nuclear antigen [Source:HGNC Symbol;Acc:HGNC:11206]
Entrez Summary This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Ensembl ID: ENSG00000067066
External Link: CisBP
Interpro IPR000770; IPR001487; IPR001965; IPR004865; IPR009071; IPR010919; IPR011011; IPR019786; IPR019787; ;
Protein Domain: ENSP00000264052
Protein Domain: ENSP00000343023
Protein Domain: ENSP00000386427
Protein Domain: ENSP00000386404
Protein Domain: ENSP00000393679
Protein Domain: ENSP00000386998
Protein Domain: ENSP00000399389
Protein Domain: ENSP00000416563
Protein Domain: ENSP00000400277
Protein Domain: ENSP00000391616
Protein: ENSP00000264052DBD: HMGOther: HSR
Protein: ENSP00000343023DBD: HMGOther: Bromodomain, HSR, PHD
Protein: ENSP00000386427DBD: HMGOther: HSR
Protein: ENSP00000386404DBD: HMGOther: HSR
Protein: ENSP00000393679DBD: HMGOther: Bromodomain, PHD
Protein: ENSP00000386998DBD: HMGOther: HSR
Protein: ENSP00000399389DBD: HMGOther: HSR
Protein: ENSP00000416563DBD: HMGOther:
Protein: ENSP00000400277DBD: HMGOther:
Protein: ENSP00000391616DBD: HMGOther: HSR

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0043433
negative regulation of sequence-specific DNA binding transcription factor activity
IDA - PMID:15247905
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution