TF Info Page for ZFAT (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Has a putative AT-hook

Description

Description: zinc finger and AT-hook domain containing [Source:HGNC Symbol;Acc:HGNC:19899]
Entrez Summary This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Ensembl ID: ENSG00000066827
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000367069
Protein Domain: ENSP00000394501
Protein Domain: ENSP00000428483
Protein Domain: ENSP00000427879
Protein Domain: ENSP00000427831
Protein Domain: ENSP00000429091
Protein Domain: ENSP00000429600
Domain:
Protein: ENSP00000367069DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4, zf-Di19, zf-H2C2_5
Protein: ENSP00000394501DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4, zf-Di19, zf-H2C2_5
Protein: ENSP00000428483DBD: C2H2 ZF Containing ProteinsOther: zf-Di19
Protein: ENSP00000427879DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4, zf-Di19, zf-H2C2_5
Protein: ENSP00000427831DBD: C2H2 ZF Containing ProteinsOther: zf-Di19
Protein: ENSP00000429091DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4, zf-Di19, zf-H2C2_5
Protein: ENSP00000429600DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution