Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
High-throughput in vitro
Description
Description:
Myb/SANT DNA binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:23370]
Entrez Summary
TBA
Ensembl ID:
ENSG00000066697
External Link:
T109615_1.02
Interpro
IPR028002 ; ;
Protein Domain:
Protein: ENSP00000378506DBD: MADFOther: Protein: ENSP00000364020DBD: MADFOther: Protein: ENSP00000480445DBD: MADFOther: Protein: ENSP00000364021DBD: MADFOther: Protein: ENSP00000415830DBD: MADFOther: Protein: ENSP00000480622DBD: MADFOther:
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0053, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 276}
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0011, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 160}
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0053, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 276}
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0014, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 181}
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0007, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 134}
{"regions": [{"startStyle": "curved", "end": 104, "endStyle": "jagged", "aliStart": 21, "text": "MADF", "colour": "#228B22", "aliEnd": 89, "start": 21, "href": "http://pfam.xfam.org/family/PF10545.7", "type": "pfama", "display": "true", "metadata": {"end": 104, "description": "The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. ", "database": "PfamA", "aliStart": 21, "scoreName": "E-value", "accession": "PF10545.7", "start": 21, "score": 0.0053, "identifier": "Alcohol dehydrogenase transcription factor Myb/SANT-like", "type": "DBD", "aliEnd": 89}}], "length": 276}