TF Info Page for SPEN (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 1 Monomer or homomultimer | No motif | Has a putative AT-hook | Data inconclusive. Contains RRM domains, suggesting RNA binding activity. Gel-shift experiments demonstrate that SPEN (aka MINT) binds ss and dsDNA G- and T-rich elements (PMID: 10451362), but in another system SPEN does not bind DNA directly and is recruited (PMID: 15778499). RNA-binding activities have also been documented (PMID: 24748666). |
Description
| Description: | spen family transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:17575] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000065526 | |
| External Link: | ||
| Interpro | IPR000504; IPR010912; IPR012921; IPR016194; | |
| Protein Domain: | ||
| Protein: | DBD: Other | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_Single stranded RNA/DNA binding_DNA Binding_ PMIDS:10451362 15778499 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | No |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
5a, one of the source datasets predicts is as a TF |
| TF has conditional DNA-binding requirements |