TF Info Page for POU1F1 (Homeodomain; POU)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: POU class 1 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9210]
Entrez Summary NA
Ensembl ID: ENSG00000064835
External Link: CisBP
Interpro IPR000327; IPR001356; IPR009057; IPR010982; IPR013847; IPR017970;
Protein Domain: ENSP00000263781
Protein Domain: ENSP00000342931
Protein Domain: ENSP00000452610
Protein Domain: ENSP00000454072
Domain:
Protein: ENSP00000263781DBD: Homeodomain,POUOther:
Protein: ENSP00000342931DBD: Homeodomain,POUOther:
Protein: ENSP00000452610DBD: Homeodomain,POUOther:
Protein: ENSP00000454072DBD: Homeodomain,POUOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:26612202
GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:11301317, PMID:9482665
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERInferred - Pou1f1 (97% AA Identity, Rattus norvegicus)
MiscHOMERInferred - Pou1f1 (97% AA Identity, Rattus norvegicus)
PBMBerger08Inferred - Pou1f1 (96% AA Identity, Mus musculus)
PBMDREAM_contestInferred - Pou1f1 (96% AA Identity, Mus musculus)
PBMDREAM_contestInferred - Pou1f1 (95% AA Identity, Mus musculus)
PBMTF_EvolutionUnpublished DataInferred - NEMVEDRAFT_v1g112929 (78% AA Identity, Nematostella vectensis)

Structure

Structure PDB 1AU7

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution