TF Info Page for DLX3 (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: distal-less homeobox 3 [Source:HGNC Symbol;Acc:HGNC:2916]
Entrez Summary NA
Ensembl ID: ENSG00000064195
External Link: CisBP
Interpro IPR000047; IPR001356; IPR009057; IPR017970; IPR020479; IPR022135;
Protein Domain: ENSP00000389870
Protein Domain: ENSP00000449976
Domain:
Protein: ENSP00000389870DBD: HomeodomainOther: DLL_N
Protein: ENSP00000449976DBD: HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
TF PPI_
PMIDS:16687405
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:9467018
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBerger08Inferred - Dlx3 (100% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - P53774 (100% AA Identity, Xenopus laevis)
HT-SELEXYin2017Inferred - DLX2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX2 (94% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dlx2 (94% AA Identity, Mus musculus)
MiscHocoMocoInferred - DLX2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX5 (91% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dlx5 (91% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - DLX5 (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX1 (87% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX1 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX1 (87% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX1 (87% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dlx1 (87% AA Identity, Mus musculus)
B1HJASPARInferred - Dll (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dll (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dll (85% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Dll (85% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - DLX6 (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX6 (85% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX6 (85% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DLX4 (82% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dlx4 (82% AA Identity, Mus musculus)

Structure

Structure PDB 4XRS

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution