TF Info Page for AHRR (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: aryl-hydrocarbon receptor repressor [Source:HGNC Symbol;Acc:HGNC:346]
Entrez Summary The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Ensembl ID: ENSG00000063438
External Link: CisBP
Interpro IPR000014; IPR011598; IPR013767; ;
Protein Domain: ENSP00000323816
Protein Domain: ENSP00000424601
Protein Domain: ENSP00000426932
Protein Domain: ENSP00000429944
Protein Domain: ENSP00000426076
Domain:
Protein: ENSP00000323816DBD: bHLHOther: PAS, PAS_4
Protein: ENSP00000424601DBD: bHLHOther: PAS, PAS_4
Protein: ENSP00000426932DBD: bHLHOther:
Protein: ENSP00000429944DBD: bHLHOther:
Protein: ENSP00000426076DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - AHR (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - AHR (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - AHR (79% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - AHR (79% AA Identity, Homo sapiens)
MiscHocoMocoInferred - AHR (79% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution