The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Solid data presented in (PMID: 14612417) Also known as Vasculin. (PMID: 26156556) also claims it has an extended AT hook.

Description

Description:	GC-rich promoter binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29520];Vasculin, Vasculin (also know
Entrez Summary	TBA
Ensembl ID:	ENSG00000062194
External Link:
Interpro	IPR028128;
Protein Domain:
Protein: ENSP00000264779	DBD: Other	Other: ELL, Vasculin
Protein: ENSP00000421202	DBD: Other	Other: ELL, Vasculin
Protein: ENSP00000421709	DBD: Other	Other: ELL, Vasculin
Protein: ENSP00000422337	DBD: Other	Other: Vasculin

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	No
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "straight", "end": 478, "endStyle": "straight", "aliStart": 382, "text": "Vasculin", "colour": "#9999ff", "aliEnd": 478, "start": 382, "href": "http://pfam.xfam.org/family/PF15337.4", "type": "pfama", "display": "true", "metadata": {"end": 478, "description": "GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.", "database": "PfamA", "aliStart": 382, "scoreName": "E-value", "accession": "PF15337.4", "start": 382, "score": 9.300000000000001e-42, "identifier": "Vascular protein family Vasculin-like 1", "type": "DBD", "aliEnd": 478}}, {"startStyle": "jagged", "end": 355, "endStyle": "jagged", "aliStart": 258, "text": "ELL", "colour": "#9999ff", "aliEnd": 324, "start": 104, "href": "http://pfam.xfam.org/family/PF10390.7", "type": "pfama", "display": "true", "metadata": {"end": 355, "description": "ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [1]. Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.", "database": "PfamA", "aliStart": 258, "scoreName": "E-value", "accession": "PF10390.7", "start": 104, "score": 0.0024, "identifier": "RNA polymerase II elongation factor ELL  ", "type": "DBD", "aliEnd": 324}}], "length": 481}

{"regions": [{"startStyle": "straight", "end": 471, "endStyle": "straight", "aliStart": 375, "text": "Vasculin", "colour": "#9999ff", "aliEnd": 471, "start": 375, "href": "http://pfam.xfam.org/family/PF15337.4", "type": "pfama", "display": "true", "metadata": {"end": 471, "description": "GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.", "database": "PfamA", "aliStart": 375, "scoreName": "E-value", "accession": "PF15337.4", "start": 375, "score": 9.1e-42, "identifier": "Vascular protein family Vasculin-like 1", "type": "DBD", "aliEnd": 471}}, {"startStyle": "jagged", "end": 348, "endStyle": "jagged", "aliStart": 251, "text": "ELL", "colour": "#9999ff", "aliEnd": 317, "start": 97, "href": "http://pfam.xfam.org/family/PF10390.7", "type": "pfama", "display": "true", "metadata": {"end": 348, "description": "ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [1]. Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.", "database": "PfamA", "aliStart": 251, "scoreName": "E-value", "accession": "PF10390.7", "start": 97, "score": 0.0023, "identifier": "RNA polymerase II elongation factor ELL  ", "type": "DBD", "aliEnd": 317}}], "length": 474}

{"regions": [{"startStyle": "straight", "end": 300, "endStyle": "straight", "aliStart": 204, "text": "Vasculin", "colour": "#9999ff", "aliEnd": 300, "start": 204, "href": "http://pfam.xfam.org/family/PF15337.4", "type": "pfama", "display": "true", "metadata": {"end": 300, "description": "GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.", "database": "PfamA", "aliStart": 204, "scoreName": "E-value", "accession": "PF15337.4", "start": 204, "score": 4e-42, "identifier": "Vascular protein family Vasculin-like 1", "type": "DBD", "aliEnd": 300}}, {"startStyle": "jagged", "end": 180, "endStyle": "jagged", "aliStart": 81, "text": "ELL", "colour": "#9999ff", "aliEnd": 146, "start": 29, "href": "http://pfam.xfam.org/family/PF10390.7", "type": "pfama", "display": "true", "metadata": {"end": 180, "description": "ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [1]. Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.", "database": "PfamA", "aliStart": 81, "scoreName": "E-value", "accession": "PF10390.7", "start": 29, "score": 0.0015, "identifier": "RNA polymerase II elongation factor ELL  ", "type": "DBD", "aliEnd": 146}}], "length": 303}

TF Info Page for GPBP1 (Unknown)