TF Info Page for FLYWCH1 (FLYWCH)


Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID: 18794349 and PMID: 15165844).


Description: FLYWCH-type zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25404]
Entrez Summary NA
Ensembl ID: ENSG00000059122
External Link: CisBP
Interpro IPR007588; IPR029279;
Protein Domain: ENSP00000253928
Protein Domain: ENSP00000344122
Protein Domain: ENSP00000399938
Protein Domain: ENSP00000458661
Protein Domain: ENSP00000458282
Protein Domain: ENSP00000461566
Protein Domain: ENSP00000458689
Protein Domain: ENSP00000459326
Protein Domain: ENSP00000459480
Protein: ENSP00000253928DBD: FLYWCHOther: FLYWCH_N, FLYWCH_u
Protein: ENSP00000344122DBD: FLYWCHOther: FLYWCH_u
Protein: ENSP00000399938DBD: FLYWCHOther: FLYWCH_N, FLYWCH_u
Protein: ENSP00000458661DBD: FLYWCHOther: FLYWCH_u
Protein: ENSP00000458282DBD: FLYWCHOther: FLYWCH_N
Protein: ENSP00000461566DBD: FLYWCHOther:
Protein: ENSP00000458689DBD: FLYWCHOther:
Protein: ENSP00000459326DBD: FLYWCHOther: FLYWCH_N
Protein: ENSP00000459480DBD: FLYWCHOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution