The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID: 18794349 and PMID: 15165844).

Description

Description:	FLYWCH-type zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25404]
Entrez Summary	TBA
Ensembl ID:	ENSG00000059122
External Link:
Interpro	IPR007588; IPR029279;
Protein Domain:
Protein: ENSP00000253928	DBD: FLYWCH	Other: FLYWCH_N, FLYWCH_u
Protein: ENSP00000344122	DBD: FLYWCH	Other: FLYWCH_u
Protein: ENSP00000399938	DBD: FLYWCH	Other: FLYWCH_N, FLYWCH_u
Protein: ENSP00000458661	DBD: FLYWCH	Other: FLYWCH_u
Protein: ENSP00000458282	DBD: FLYWCH	Other: FLYWCH_N
Protein: ENSP00000461566	DBD: FLYWCH	Other:
Protein: ENSP00000458689	DBD: FLYWCH	Other:
Protein: ENSP00000459326	DBD: FLYWCH	Other: FLYWCH_N
Protein: ENSP00000459480	DBD: FLYWCH	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 174, "endStyle": "curved", "aliStart": 116, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 174, "start": 116, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 174, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 116, "scoreName": "E-value", "accession": "PF04500.14", "start": 116, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 174}}, {"startStyle": "curved", "end": 331, "endStyle": "curved", "aliStart": 273, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 331, "start": 273, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 331, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 273, "scoreName": "E-value", "accession": "PF04500.14", "start": 273, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 331}}, {"startStyle": "curved", "end": 479, "endStyle": "curved", "aliStart": 421, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 479, "start": 421, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 479, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 421, "scoreName": "E-value", "accession": "PF04500.14", "start": 421, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 479}}, {"startStyle": "curved", "end": 567, "endStyle": "curved", "aliStart": 509, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 567, "start": 509, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 567, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 509, "scoreName": "E-value", "accession": "PF04500.14", "start": 509, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 567}}, {"startStyle": "curved", "end": 658, "endStyle": "curved", "aliStart": 600, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 658, "start": 600, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 658, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 600, "scoreName": "E-value", "accession": "PF04500.14", "start": 600, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 658}}, {"startStyle": "straight", "end": 107, "endStyle": "straight", "aliStart": 1, "text": "FLYWCH_N", "colour": "#9999ff", "aliEnd": 107, "start": 1, "href": "http://pfam.xfam.org/family/PF15423.4", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with Pfam:PF04500. There are two conserved sequence motifs: EQE and QEPS.", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF15423.4", "start": 1, "score": 1.3e-55, "identifier": "FLYWCH-type zinc finger-containing protein", "type": "DBD", "aliEnd": 107}}, {"startStyle": "straight", "end": 240, "endStyle": "jagged", "aliStart": 175, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 219, "start": 175, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 240, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 175, "scoreName": "E-value", "accession": "PF16662.3", "start": 175, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 219}}, {"startStyle": "straight", "end": 420, "endStyle": "straight", "aliStart": 332, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 420, "start": 332, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 420, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 332, "scoreName": "E-value", "accession": "PF16662.3", "start": 332, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 420}}, {"startStyle": "straight", "end": 546, "endStyle": "jagged", "aliStart": 480, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 509, "start": 480, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 546, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 480, "scoreName": "E-value", "accession": "PF16662.3", "start": 480, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 509}}, {"startStyle": "straight", "end": 689, "endStyle": "jagged", "aliStart": 659, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 677, "start": 659, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 689, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 659, "scoreName": "E-value", "accession": "PF16662.3", "start": 659, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 677}}], "length": 717}

{"regions": [{"startStyle": "curved", "end": 60, "endStyle": "curved", "aliStart": 2, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 60, "start": 2, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 60, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 2, "scoreName": "E-value", "accession": "PF04500.14", "start": 2, "score": 2.5e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 60}}, {"startStyle": "curved", "end": 208, "endStyle": "curved", "aliStart": 150, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 208, "start": 150, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 208, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 150, "scoreName": "E-value", "accession": "PF04500.14", "start": 150, "score": 2.5e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 208}}, {"startStyle": "curved", "end": 345, "endStyle": "curved", "aliStart": 287, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 345, "start": 287, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 345, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 287, "scoreName": "E-value", "accession": "PF04500.14", "start": 287, "score": 2.5e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 345}}, {"startStyle": "curved", "end": 436, "endStyle": "curved", "aliStart": 378, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 436, "start": 378, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 436, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 378, "scoreName": "E-value", "accession": "PF04500.14", "start": 378, "score": 2.5e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 436}}, {"startStyle": "straight", "end": 149, "endStyle": "straight", "aliStart": 61, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 149, "start": 61, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 149, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 61, "scoreName": "E-value", "accession": "PF16662.3", "start": 61, "score": 3.1e-44, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 149}}, {"startStyle": "straight", "end": 247, "endStyle": "jagged", "aliStart": 209, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 235, "start": 209, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 247, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 209, "scoreName": "E-value", "accession": "PF16662.3", "start": 209, "score": 3.1e-44, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 235}}, {"startStyle": "straight", "end": 467, "endStyle": "jagged", "aliStart": 437, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 455, "start": 437, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 467, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 437, "scoreName": "E-value", "accession": "PF16662.3", "start": 437, "score": 3.1e-44, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 455}}], "length": 495}

{"regions": [{"startStyle": "curved", "end": 173, "endStyle": "curved", "aliStart": 115, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 173, "start": 115, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 173, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 115, "scoreName": "E-value", "accession": "PF04500.14", "start": 115, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 173}}, {"startStyle": "curved", "end": 330, "endStyle": "curved", "aliStart": 272, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 330, "start": 272, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 330, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 272, "scoreName": "E-value", "accession": "PF04500.14", "start": 272, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 330}}, {"startStyle": "curved", "end": 478, "endStyle": "curved", "aliStart": 420, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 478, "start": 420, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 478, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 420, "scoreName": "E-value", "accession": "PF04500.14", "start": 420, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 478}}, {"startStyle": "curved", "end": 566, "endStyle": "curved", "aliStart": 508, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 566, "start": 508, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 566, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 508, "scoreName": "E-value", "accession": "PF04500.14", "start": 508, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 566}}, {"startStyle": "curved", "end": 657, "endStyle": "curved", "aliStart": 599, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 657, "start": 599, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 657, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 599, "scoreName": "E-value", "accession": "PF04500.14", "start": 599, "score": 2.6999999999999996e-72, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 657}}, {"startStyle": "straight", "end": 107, "endStyle": "straight", "aliStart": 1, "text": "FLYWCH_N", "colour": "#9999ff", "aliEnd": 107, "start": 1, "href": "http://pfam.xfam.org/family/PF15423.4", "type": "pfama", "display": "true", "metadata": {"end": 107, "description": "This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with Pfam:PF04500. There are two conserved sequence motifs: EQE and QEPS.", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF15423.4", "start": 1, "score": 1.3e-55, "identifier": "FLYWCH-type zinc finger-containing protein", "type": "DBD", "aliEnd": 107}}, {"startStyle": "straight", "end": 239, "endStyle": "jagged", "aliStart": 174, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 218, "start": 174, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 239, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 174, "scoreName": "E-value", "accession": "PF16662.3", "start": 174, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 218}}, {"startStyle": "straight", "end": 419, "endStyle": "straight", "aliStart": 331, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 419, "start": 331, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 419, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 331, "scoreName": "E-value", "accession": "PF16662.3", "start": 331, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 419}}, {"startStyle": "straight", "end": 545, "endStyle": "jagged", "aliStart": 479, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 508, "start": 479, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 545, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 479, "scoreName": "E-value", "accession": "PF16662.3", "start": 479, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 508}}, {"startStyle": "straight", "end": 688, "endStyle": "jagged", "aliStart": 658, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 676, "start": 658, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 688, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 658, "scoreName": "E-value", "accession": "PF16662.3", "start": 658, "score": 1.2999999999999999e-46, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 676}}], "length": 716}

{"regions": [{"startStyle": "curved", "end": 94, "endStyle": "curved", "aliStart": 36, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 94, "start": 36, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 94, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 36, "scoreName": "E-value", "accession": "PF04500.14", "start": 36, "score": 1.9e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 94}}, {"startStyle": "curved", "end": 242, "endStyle": "curved", "aliStart": 184, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 242, "start": 184, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 242, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 184, "scoreName": "E-value", "accession": "PF04500.14", "start": 184, "score": 1.9e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 242}}, {"startStyle": "curved", "end": 330, "endStyle": "curved", "aliStart": 272, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 330, "start": 272, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 330, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 272, "scoreName": "E-value", "accession": "PF04500.14", "start": 272, "score": 1.9e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 330}}, {"startStyle": "curved", "end": 421, "endStyle": "curved", "aliStart": 363, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 421, "start": 363, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 421, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 363, "scoreName": "E-value", "accession": "PF04500.14", "start": 363, "score": 1.9e-59, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 421}}, {"startStyle": "straight", "end": 183, "endStyle": "straight", "aliStart": 95, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 183, "start": 95, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 183, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 95, "scoreName": "E-value", "accession": "PF16662.3", "start": 95, "score": 5.099999999999999e-45, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 183}}, {"startStyle": "straight", "end": 312, "endStyle": "jagged", "aliStart": 243, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 272, "start": 243, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 312, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 243, "scoreName": "E-value", "accession": "PF16662.3", "start": 243, "score": 5.099999999999999e-45, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 272}}, {"startStyle": "straight", "end": 452, "endStyle": "jagged", "aliStart": 422, "text": "FLYWCH_u", "colour": "#9999ff", "aliEnd": 440, "start": 422, "href": "http://pfam.xfam.org/family/PF16662.3", "type": "pfama", "display": "true", "metadata": {"end": 452, "description": "FLYWCH_u is a region of natively unstructured but conserved sequence that lies between the FLYWCH zinc-finger domains on FLYWCH-type zinc finger-containing protein 1 proteins in higher eukaryotes. The function is not known but the N- and C-termini are likely to be part of the zinc-finger domains specific, to the eukaryotes.", "database": "PfamA", "aliStart": 422, "scoreName": "E-value", "accession": "PF16662.3", "start": 422, "score": 5.099999999999999e-45, "identifier": "FLYWCH-type zinc finger-containing protein 1", "type": "DBD", "aliEnd": 440}}], "length": 468}

{"regions": [{"startStyle": "jagged", "end": 36, "endStyle": "curved", "aliStart": 2, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 36, "start": 1, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 36, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 2, "scoreName": "E-value", "accession": "PF04500.14", "start": 1, "score": 2.9999999999999997e-20, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 36}}, {"startStyle": "curved", "end": 198, "endStyle": "jagged", "aliStart": 153, "text": "FLYWCH", "colour": "#228B22", "aliEnd": 198, "start": 153, "href": "http://pfam.xfam.org/family/PF04500.14", "type": "pfama", "display": "true", "metadata": {"end": 198, "description": "Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].", "database": "PfamA", "aliStart": 153, "scoreName": "E-value", "accession": "PF04500.14", "start": 153, "score": 2.9999999999999997e-20, "identifier": "FLYWCH zinc finger domain", "type": "DBD", "aliEnd": 198}}], "length": 198}

TF Info Page for FLYWCH1 (FLYWCH)