TF Info Page for FOXN3 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928]
Entrez Summary NA
Ensembl ID: ENSG00000053254
External Link: CisBP
Interpro IPR001766; IPR018122;
Protein Domain: ENSP00000261302
Protein Domain: ENSP00000343288
Protein Domain: ENSP00000452227
Protein Domain: ENSP00000452005
Protein Domain: ENSP00000479114
Protein Domain: ENSP00000452444
Protein Domain: ENSP00000451902
Protein Domain: ENSP00000452290
Protein Domain: ENSP00000450684
Protein Domain: ENSP00000450783
Domain:
Protein: ENSP00000261302DBD: ForkheadOther:
Protein: ENSP00000343288DBD: ForkheadOther:
Protein: ENSP00000452227DBD: ForkheadOther:
Protein: ENSP00000452005DBD: ForkheadOther:
Protein: ENSP00000479114DBD: ForkheadOther:
Protein: ENSP00000452444DBD: ForkheadOther:
Protein: ENSP00000451902DBD: ForkheadOther:
Protein: ENSP00000452290DBD: ForkheadOther:
Protein: ENSP00000450684DBD: ForkheadOther:
Protein: ENSP00000450783DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMTF_EvolutionUnpublished DataDirect
PBMNakagawa2013Inferred - FOXN2 (74% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FOXN2 (74% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXN2 (74% AA Identity, Homo sapiens)
PBMNakagawa2013Inferred - NEMVEDRAFT_v1g67209 (74% AA Identity, Nematostella vectensis)
PBMNakagawa2013Inferred - TriadG17577 (74% AA Identity, Trichoplax adhaerens)
TransfacTransfacLicense requiredInferred - FOXN2 (74% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXN2 (74% AA Identity, Homo sapiens)
PBMNakagawa2013Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CHES-1-like (70% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution