get eID ENSG00000037965 else done selects

TF Info Page for HOXC8 (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: homeobox C8 [Source:HGNC Symbol;Acc:HGNC:5129]
Entrez Summary TBA
Ensembl ID: ENSG00000037965
External Link: T093229_1.02
Interpro IPR000047; IPR001356; IPR001827; IPR009057; IPR017970; IPR020479;
Protein Domain:
Protein: ENSP00000040584DBD: HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBerger08Inferred - Hoxc8 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB8 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB8 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB8 (98% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb8 (98% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXB8 (98% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD8 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD8 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD8 (94% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxd8 (92% AA Identity, Mus musculus)
B1HJASPARInferred - Antp (82% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HOXA6 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA6 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA6 (82% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa6 (82% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXA7 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA7 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA7 (82% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa7 (82% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxa7 (82% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB6 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB6 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB6 (82% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb6 (82% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxc6 (82% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Antp (82% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - HOXA7 (82% AA Identity, Homo sapiens)
MisciDMMPMMInferred - Antp (82% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - HOXA7 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXB6 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXC6 (82% AA Identity, Homo sapiens)
B1HJASPARInferred - abd-A (80% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - abd-A (80% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - abd-A (80% AA Identity, Drosophila melanogaster)
PBMBusserDevelopment2012Inferred - Ubx (80% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Ubx (80% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Ubx (80% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - abd-A (80% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Ubx (80% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - abd-A (80% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - Ubx (80% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - HOXB7 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB7 (78% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb7 (78% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXB7 (78% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - HOXB7 (77% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - HOXB7 (77% AA Identity, Homo sapiens)
B1HJASPARInferred - Scr (77% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Scr (77% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - Cbr-mab-5 (75% AA Identity, Caenorhabditis briggsae)
HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA5 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa5 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB5 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb5 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXC9 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC9 (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc9 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD9 (75% AA Identity, Homo sapiens)
COMPILEDJASPARInferred - HOXA5 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA5 (75% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Hoxc9 (75% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HOXD9 (75% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXA5 (75% AA Identity, Homo sapiens)
MiscHOMERInferred - Hoxc9 (75% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXD9 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA9 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA9 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA9 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA9 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa9 (73% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXB9 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXB9 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB9 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb9 (73% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HOXA9 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HOXA9 (73% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Hoxa9 (73% AA Identity, Mus musculus)
MiscHocoMocoInferred - HOXA9 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXA9 (73% AA Identity, Homo sapiens)
MiscHOMERInferred - Hoxa9 (73% AA Identity, Mus musculus)
B1HJASPARInferred - ftz (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - ftz (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HOXA4 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA4 (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa4 (71% AA Identity, Mus musculus)
PBMBerger08Inferred - Hoxc5 (71% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ftz (71% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - HOXA4 (71% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - lin-39 (71% AA Identity, Caenorhabditis elegans)
MisciDMMPMMInferred - ftz (71% AA Identity, Drosophila melanogaster)
MiscHOMERInferred - lin-39 (71% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXA10 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxa10 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC10 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc10 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD10 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxd10 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXD4 (70% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Hoxa10 (70% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - HOXD10 (70% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXD10 (70% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HOXD4 (70% AA Identity, Homo sapiens)
B1HJASPARInferred - Dfd (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dfd (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Dfd (68% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HOXB4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXB4 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxb4 (68% AA Identity, Mus musculus)
PBMBarrera2016Inferred - HOXC4 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - HOXC4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HOXC4 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Hoxc4 (68% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Dfd (68% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - Dfd (68% AA Identity, Drosophila melanogaster)
MiscHOMERInferred - Hoxb4 (68% AA Identity, Mus musculus)
PBMBusserDevelopment2012Inferred - Abd-B (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Abd-B (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Abd-B (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Abd-B (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Abd-B (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Abd-B (66% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - HOXC4 (66% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Q0N4M8_NEMVE (66% AA Identity, Nematostella vectensis)
TransfacTransfacLicense requiredInferred - Abd-B (66% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Abd-B (66% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - Abd-B (66% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution