Only known motifs are from Transfac or HocoMoco - origin is uncertain
Description
Description:
IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177]
Entrez Summary
This gene encodes a member of the Ikaros family of zinc-finger
proteins. Three members of this protein family (Ikaros, Aiolos and Helios)
are hematopoietic-specific transcription factors involved in the regulation
of lymphocyte development. This protein forms homo- or hetero-dimers with
other Ikaros family members, and is thought to function predominantly in
early hematopoietic development. Multiple transcript variants encoding
different isoforms have been found for this gene, but the biological validity
of some variants has not been determined. [provided by RefSeq, Jul 2008]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0003700 sequence-specific DNA binding transcription factor activity IBA - GO_REF:0000033
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF