TF Info Page for IKZF2 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177]
Entrez Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000030419
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000342876
Protein Domain: ENSP00000363439
Protein Domain: ENSP00000402132
Protein Domain: ENSP00000406783
Domain:
Protein: ENSP00000342876DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000363439DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000402132DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000406783DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - IKZF1 (90% AA Identity, Homo sapiens)
MiscHocoMocoInferred - IKZF1 (90% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution