TF Info Page for ARNTL2 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer High-throughput in vitro ARNTL2 Forms heterodimers with CLOCK and NPAS2 (PMID:10864977 ).

Description

Description: aryl hydrocarbon receptor nuclear translocator like 2 [Source:HGNC Symbol;Acc:HGNC:18984]
Entrez Summary This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Ensembl ID: ENSG00000029153
External Link: CisBP
Interpro IPR000014; IPR001067; IPR011598; IPR013767;
Protein Domain: ENSP00000261178
Protein Domain: ENSP00000266503
Protein Domain: ENSP00000312247
Protein Domain: ENSP00000379238
Protein Domain: ENSP00000400185
Protein Domain: ENSP00000445836
Protein Domain: ENSP00000438545
Domain:
Protein: ENSP00000261178DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9
Protein: ENSP00000266503DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9
Protein: ENSP00000312247DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9
Protein: ENSP00000379238DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9
Protein: ENSP00000400185DBD: bHLHOther: PAS, PAS_11, PAS_3, PAS_4, PAS_9
Protein: ENSP00000445836DBD: bHLHOther: PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9
Protein: ENSP00000438545DBD: bHLHOther: PAS, PAS_11, PAS_2, PAS_3, PAS_4, PAS_9

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000982
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:15147242
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:12055078 | NAS - PMID:11018023
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - ARNTL (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ARNTL (68% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Arntl (68% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - cyc (68% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - ARNTL (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Arntl (68% AA Identity, Rattus norvegicus)
MiscHocoMocoInferred - ARNTL (68% AA Identity, Homo sapiens)
MiscHOMERInferred - Arntl (68% AA Identity, Mus musculus)
PBMZoo_01Inferred - Arnt (56% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ARNT2 (56% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Arnt2 (56% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ARNT (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ARNT (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ARNT (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Arnt2 (56% AA Identity, Rattus norvegicus)
MiscHocoMocoInferred - ARNT (56% AA Identity, Homo sapiens)
MiscHOMERInferred - ARNT (56% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ARNT2 (56% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution