TF Info Page for TBPL1 (TBP)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Likely to be sequence specific TF | 2 Obligate heteromer | No motif | A more distant paralog of TBP and the only member of the TBP family that lacks the ability to bind the TATA box. (PMID: 21711503). In vitro, purified TLF-TFIIA binds directly to the NF1 promoter (PMID: 15767669), so likely an obligate heteromer. |
Description
| Description: | TATA-box binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:11589] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000028839 | |
| External Link: | ||
| Interpro | IPR000814; ; | |
| Protein Domain: | ||
| Protein: ENSP00000237264 | DBD: TBP | Other: |
| Protein: ENSP00000356845 | DBD: TBP | Other: |
| Protein: ENSP00000478795 | DBD: TBP | Other: |
| Protein: ENSP00000356843 | DBD: TBP | Other: |
| Protein: ENSP00000402864 | DBD: TBP | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene Candidate_DNA-Binding sequence-specific_Other_ PMIDS:11352070 15767669 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
| TF has conditional DNA-binding requirements |