get eID ENSG00000025434 else done selects

TF Info Page for NR1H3 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer In vivo/Misc source Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA

Description

Description: nuclear receptor subfamily 1 group H member 3 [Source:HGNC Symbol;Acc:HGNC:7966]
Entrez Summary TBA
Ensembl ID: ENSG00000025434
External Link:
Interpro IPR000536; IPR001628; IPR001723; IPR008946; IPR023257; ;
Protein Domain:
Protein: ENSP00000378793DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000384745DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000387946DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000420656DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000432073DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000403798DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000396132DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000391005DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000434650DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9013544
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
TAS - PMID:7744246
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
MiscHocoMocoInferred - NR1H2 (73% AA Identity, Homo sapiens)
MiscHOMERInferred - Nr1h2 (72% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - AAM33367 (70% AA Identity, Xenopus laevis)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution