Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Likely to be sequence specific TF
1 Monomer or homomultimer
No motif
Description
Description:
PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098]
Entrez Summary
TBA
Ensembl ID:
ENSG00000025293
External Link:
Interpro
IPR001965 ; IPR002999 ; IPR007087 ; IPR011011 ; IPR019786 ; IPR019787 ; IPR022255 ; ;
Protein Domain:
Protein: ENSP00000363112DBD: OtherOther: DUF3776, DUF4537, LBR_tudor, MBT, Rad9_Rad53_bind,Protein: ENSP00000363124DBD: OtherOther: DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, PHD, RaProtein: ENSP00000341900DBD: OtherOther: DUF1325, DUF3776, DUF4537, LBR_tudor, MBT, Rad9_RaProtein: ENSP00000413712DBD: OtherOther:
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "straight", "end": 267, "endStyle": "straight", "aliStart": 177, "text": "DUF3776", "colour": "#9999ff", "aliEnd": 258, "start": 176, "href": "http://pfam.xfam.org/family/PF12618.6", "type": "pfama", "display": "true", "metadata": {"end": 267, "description": "This domain family is found in eukaryotes, and is approximately 100 amino acids in length.", "database": "PfamA", "aliStart": 177, "scoreName": "E-value", "accession": "PF12618.6", "start": 176, "score": 6.2e-28, "identifier": "Protein of unknown function (DUF3776)", "type": "DBD", "aliEnd": 258}}, {"startStyle": "straight", "end": 73, "endStyle": "jagged", "aliStart": 19, "text": "MBT", "colour": "#9999ff", "aliEnd": 68, "start": 18, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 73, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 19, "scoreName": "E-value", "accession": "PF02820.16", "start": 18, "score": 0.00015, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 68}}, {"startStyle": "jagged", "end": 141, "endStyle": "jagged", "aliStart": 29, "text": "DUF4537", "colour": "#9999ff", "aliEnd": 133, "start": 21, "href": "http://pfam.xfam.org/family/PF15057.4", "type": "pfama", "display": "true", "metadata": {"end": 141, "description": "The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.", "database": "PfamA", "aliStart": 29, "scoreName": "E-value", "accession": "PF15057.4", "start": 21, "score": 0.00022, "identifier": "Domain of unknown function (DUF4537)", "type": "DBD", "aliEnd": 133}}, {"startStyle": "straight", "end": 134, "endStyle": "straight", "aliStart": 84, "text": "LBR_tudor", "colour": "#9999ff", "aliEnd": 130, "start": 83, "href": "http://pfam.xfam.org/family/PF09465.8", "type": "pfama", "display": "true", "metadata": {"end": 134, "description": "The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE [1].", "database": "PfamA", "aliStart": 84, "scoreName": "E-value", "accession": "PF09465.8", "start": 83, "score": 0.0014, "identifier": "Lamin-B receptor of TUDOR domain", "type": "DBD", "aliEnd": 130}}, {"startStyle": "straight", "end": 137, "endStyle": "jagged", "aliStart": 92, "text": "Rad9_Rad53_bind", "colour": "#9999ff", "aliEnd": 133, "start": 85, "href": "http://pfam.xfam.org/family/PF08605.8", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": "In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains [1]. This region is structurally composed of a pair of TUDOR domains [1].", "database": "PfamA", "aliStart": 92, "scoreName": "E-value", "accession": "PF08605.8", "start": 85, "score": 0.0025, "identifier": "Fungal Rad9-like Rad53-binding", "type": "DBD", "aliEnd": 133}}, {"startStyle": "straight", "end": 59, "endStyle": "jagged", "aliStart": 14, "text": "Tudor-knot", "colour": "#9999ff", "aliEnd": 57, "start": 13, "href": "http://pfam.xfam.org/family/PF11717.6", "type": "pfama", "display": "true", "metadata": {"end": 59, "description": "This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].", "database": "PfamA", "aliStart": 14, "scoreName": "E-value", "accession": "PF11717.6", "start": 13, "score": 0.0088, "identifier": "RNA binding activity-knot of a chromodomain ", "type": "DBD", "aliEnd": 57}}], "length": 549}
{"regions": [{"startStyle": "straight", "end": 265, "endStyle": "straight", "aliStart": 177, "text": "DUF3776", "colour": "#9999ff", "aliEnd": 258, "start": 176, "href": "http://pfam.xfam.org/family/PF12618.6", "type": "pfama", "display": "true", "metadata": {"end": 265, "description": "This domain family is found in eukaryotes, and is approximately 100 amino acids in length.", "database": "PfamA", "aliStart": 177, "scoreName": "E-value", "accession": "PF12618.6", "start": 176, "score": 3e-27, "identifier": "Protein of unknown function (DUF3776)", "type": "DBD", "aliEnd": 258}}, {"startStyle": "straight", "end": 700, "endStyle": "straight", "aliStart": 654, "text": "PHD", "colour": "#9999ff", "aliEnd": 698, "start": 654, "href": "http://pfam.xfam.org/family/PF00628.27", "type": "pfama", "display": "true", "metadata": {"end": 700, "description": "PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2]. Several PHD fingers have been identified as binding modules of methylated histone H3 [3].", "database": "PfamA", "aliStart": 654, "scoreName": "E-value", "accession": "PF00628.27", "start": 654, "score": 6e-07, "identifier": "PHD-finger", "type": "DBD", "aliEnd": 698}}, {"startStyle": "jagged", "end": 136, "endStyle": "jagged", "aliStart": 71, "text": "DUF1325", "colour": "#9999ff", "aliEnd": 126, "start": 65, "href": "http://pfam.xfam.org/family/PF07039.9", "type": "pfama", "display": "true", "metadata": {"end": 136, "description": "This domain is found in the yeast protein SAGA-associated factor 29. This domain is related to members of the Tudor domain superfamily such as Pfam:PF05641. The SAGA complex is involved in RNA polymerase II-dependent transcriptional regulation. The membership of the tudor domain superfamily suggests this domain may bind to RNA.", "database": "PfamA", "aliStart": 71, "scoreName": "E-value", "accession": "PF07039.9", "start": 65, "score": 9.8e-05, "identifier": "SGF29 tudor-like domain", "type": "DBD", "aliEnd": 126}}, {"startStyle": "straight", "end": 73, "endStyle": "jagged", "aliStart": 19, "text": "MBT", "colour": "#9999ff", "aliEnd": 68, "start": 18, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 73, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 19, "scoreName": "E-value", "accession": "PF02820.16", "start": 18, "score": 0.0004, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 68}}, {"startStyle": "jagged", "end": 141, "endStyle": "jagged", "aliStart": 29, "text": "DUF4537", "colour": "#9999ff", "aliEnd": 133, "start": 21, "href": "http://pfam.xfam.org/family/PF15057.4", "type": "pfama", "display": "true", "metadata": {"end": 141, "description": "The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.", "database": "PfamA", "aliStart": 29, "scoreName": "E-value", "accession": "PF15057.4", "start": 21, "score": 0.00042, "identifier": "Domain of unknown function (DUF4537)", "type": "DBD", "aliEnd": 133}}, {"startStyle": "straight", "end": 134, "endStyle": "straight", "aliStart": 84, "text": "LBR_tudor", "colour": "#9999ff", "aliEnd": 130, "start": 83, "href": "http://pfam.xfam.org/family/PF09465.8", "type": "pfama", "display": "true", "metadata": {"end": 134, "description": "The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE [1].", "database": "PfamA", "aliStart": 84, "scoreName": "E-value", "accession": "PF09465.8", "start": 83, "score": 0.0035, "identifier": "Lamin-B receptor of TUDOR domain", "type": "DBD", "aliEnd": 130}}, {"startStyle": "straight", "end": 137, "endStyle": "jagged", "aliStart": 92, "text": "Rad9_Rad53_bind", "colour": "#9999ff", "aliEnd": 133, "start": 85, "href": "http://pfam.xfam.org/family/PF08605.8", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": "In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains [1]. This region is structurally composed of a pair of TUDOR domains [1].", "database": "PfamA", "aliStart": 92, "scoreName": "E-value", "accession": "PF08605.8", "start": 85, "score": 0.0085, "identifier": "Fungal Rad9-like Rad53-binding", "type": "DBD", "aliEnd": 133}}], "length": 1013}
{"regions": [{"startStyle": "straight", "end": 267, "endStyle": "straight", "aliStart": 177, "text": "DUF3776", "colour": "#9999ff", "aliEnd": 258, "start": 176, "href": "http://pfam.xfam.org/family/PF12618.6", "type": "pfama", "display": "true", "metadata": {"end": 267, "description": "This domain family is found in eukaryotes, and is approximately 100 amino acids in length.", "database": "PfamA", "aliStart": 177, "scoreName": "E-value", "accession": "PF12618.6", "start": 176, "score": 5.999999999999999e-28, "identifier": "Protein of unknown function (DUF3776)", "type": "DBD", "aliEnd": 258}}, {"startStyle": "jagged", "end": 136, "endStyle": "jagged", "aliStart": 71, "text": "DUF1325", "colour": "#9999ff", "aliEnd": 126, "start": 65, "href": "http://pfam.xfam.org/family/PF07039.9", "type": "pfama", "display": "true", "metadata": {"end": 136, "description": "This domain is found in the yeast protein SAGA-associated factor 29. This domain is related to members of the Tudor domain superfamily such as Pfam:PF05641. The SAGA complex is involved in RNA polymerase II-dependent transcriptional regulation. The membership of the tudor domain superfamily suggests this domain may bind to RNA.", "database": "PfamA", "aliStart": 71, "scoreName": "E-value", "accession": "PF07039.9", "start": 65, "score": 4.2e-05, "identifier": "SGF29 tudor-like domain", "type": "DBD", "aliEnd": 126}}, {"startStyle": "straight", "end": 73, "endStyle": "jagged", "aliStart": 19, "text": "MBT", "colour": "#9999ff", "aliEnd": 68, "start": 18, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 73, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 19, "scoreName": "E-value", "accession": "PF02820.16", "start": 18, "score": 0.00014, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 68}}, {"startStyle": "jagged", "end": 141, "endStyle": "jagged", "aliStart": 29, "text": "DUF4537", "colour": "#9999ff", "aliEnd": 133, "start": 21, "href": "http://pfam.xfam.org/family/PF15057.4", "type": "pfama", "display": "true", "metadata": {"end": 141, "description": "The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.", "database": "PfamA", "aliStart": 29, "scoreName": "E-value", "accession": "PF15057.4", "start": 21, "score": 0.00022, "identifier": "Domain of unknown function (DUF4537)", "type": "DBD", "aliEnd": 133}}, {"startStyle": "straight", "end": 134, "endStyle": "straight", "aliStart": 84, "text": "LBR_tudor", "colour": "#9999ff", "aliEnd": 130, "start": 83, "href": "http://pfam.xfam.org/family/PF09465.8", "type": "pfama", "display": "true", "metadata": {"end": 134, "description": "The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE [1].", "database": "PfamA", "aliStart": 84, "scoreName": "E-value", "accession": "PF09465.8", "start": 83, "score": 0.0013, "identifier": "Lamin-B receptor of TUDOR domain", "type": "DBD", "aliEnd": 130}}, {"startStyle": "straight", "end": 137, "endStyle": "jagged", "aliStart": 92, "text": "Rad9_Rad53_bind", "colour": "#9999ff", "aliEnd": 133, "start": 85, "href": "http://pfam.xfam.org/family/PF08605.8", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": "In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains [1]. This region is structurally composed of a pair of TUDOR domains [1].", "database": "PfamA", "aliStart": 92, "scoreName": "E-value", "accession": "PF08605.8", "start": 85, "score": 0.0024, "identifier": "Fungal Rad9-like Rad53-binding", "type": "DBD", "aliEnd": 133}}, {"startStyle": "straight", "end": 59, "endStyle": "jagged", "aliStart": 14, "text": "Tudor-knot", "colour": "#9999ff", "aliEnd": 57, "start": 13, "href": "http://pfam.xfam.org/family/PF11717.6", "type": "pfama", "display": "true", "metadata": {"end": 59, "description": "This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].", "database": "PfamA", "aliStart": 14, "scoreName": "E-value", "accession": "PF11717.6", "start": 13, "score": 0.0087, "identifier": "RNA binding activity-knot of a chromodomain ", "type": "DBD", "aliEnd": 57}}], "length": 543}