TF Info Page for SNAI2 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: snail family transcriptional repressor 2 [Source:HGNC Symbol;Acc:HGNC:11094]
Entrez Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000019549
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000020945
Protein Domain: ENSP00000380034
Domain:
Protein: ENSP00000020945DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000380034DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:10518215 16286009
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:10866665, PMID:11912130, PMID:16707493,
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBarrera2016Direct
PBMBarrera2016Direct
PBMBarrera2016Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
HT-SELEXYin2017Inferred - SNAI3 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SNAI3 (78% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - wor (78% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - wor (78% AA Identity, Drosophila melanogaster)
SMiLE-seqIsakova2017Inferred - sna (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - sna (71% AA Identity, Drosophila melanogaster)
SELEXJASPARInferred - sna (71% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - sna (71% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - sna (71% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - sna (71% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution