TF Info Page for NR1H4 (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro | Also binds DNA as heterodimer with RXRA (PMID: 11870371) |
Description
| Description: | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000012504 | |
| External Link: | ||
| Interpro | IPR000536; IPR001628; IPR001723; IPR001728; IPR008946; ; | |
| Protein Domain: | ||
| Protein: ENSP00000188403 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000376712 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000448506 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000448978 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000447149 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000446760 | DBD: Nuclear Hormone Receptor | Other: |
| Protein: ENSP00000446861 | DBD: Nuclear Hormone Receptor | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:11533040 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:24211198 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10334992, PMID:9223286 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA - PMID:21757002 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ISS - PMID:21757002 GO:0004887 thyroid hormone receptor activity IEA - GO_REF:0000002 GO:0032088 negative regulation of NF-kappaB transcription factor activity IEA - GO_REF:0000019 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |