The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Has a SLED domain (IPR021987). (PMID: 24727478) claims, based on NMR, that SLED is a sequence-specific DBD with relatively high specificity

Description

Description:	sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19003];Polycomb protein SCMH1
Entrez Summary	TBA
Ensembl ID:	ENSG00000010803
External Link:
Interpro	IPR001660; IPR004092; IPR013761; IPR021129; IPR021987;
Protein Domain:
Protein: ENSP00000318094	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000354656	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000354996	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361676	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361677	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361678	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000380356	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000337352	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000380359	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000403974	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000479881	DBD: Other	Other: SAM_1, SAM_2, SAM_PNT

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene Candidate__Other_ PMIDS:10653359
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	No
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10524249
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "straight", "end": 130, "endStyle": "straight", "aliStart": 62, "text": "MBT", "colour": "#9999ff", "aliEnd": 129, "start": 62, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 130, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 62, "scoreName": "E-value", "accession": "PF02820.16", "start": 62, "score": 1.1e-49, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 129}}, {"startStyle": "straight", "end": 238, "endStyle": "straight", "aliStart": 171, "text": "MBT", "colour": "#9999ff", "aliEnd": 236, "start": 171, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 238, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 171, "scoreName": "E-value", "accession": "PF02820.16", "start": 171, "score": 1.1e-49, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 236}}, {"startStyle": "straight", "end": 466, "endStyle": "straight", "aliStart": 358, "text": "SLED", "colour": "#9999ff", "aliEnd": 466, "start": 358, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 466, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 358, "scoreName": "E-value", "accession": "PF12140.6", "start": 358, "score": 1.4999999999999997e-36, "identifier": "SLED domain", "type": "DBD", "aliEnd": 466}}, {"startStyle": "straight", "end": 656, "endStyle": "straight", "aliStart": 591, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 656, "start": 591, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 656, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 591, "scoreName": "E-value", "accession": "PF00536.28", "start": 591, "score": 5e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 656}}, {"startStyle": "straight", "end": 324, "endStyle": "straight", "aliStart": 271, "text": "RBR", "colour": "#9999ff", "aliEnd": 324, "start": 271, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 324, "description": NaN, "database": "PfamA", "aliStart": 271, "scoreName": "E-value", "accession": "PF17208.1", "start": 271, "score": 1.9e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 324}}, {"startStyle": "straight", "end": 656, "endStyle": "straight", "aliStart": 590, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 656, "start": 590, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 656, "description": NaN, "database": "PfamA", "aliStart": 590, "scoreName": "E-value", "accession": "PF07647.15", "start": 590, "score": 6.2e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 656}}, {"startStyle": "jagged", "end": 658, "endStyle": "straight", "aliStart": 588, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 656, "start": 575, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 658, "description": NaN, "database": "PfamA", "aliStart": 588, "scoreName": "E-value", "accession": "PF02198.14", "start": 575, "score": 0.00058, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 656}}], "length": 661}

{"regions": [{"startStyle": "straight", "end": 69, "endStyle": "straight", "aliStart": 1, "text": "MBT", "colour": "#9999ff", "aliEnd": 68, "start": 1, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 69, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF02820.16", "start": 1, "score": 7.899999999999999e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 68}}, {"startStyle": "straight", "end": 177, "endStyle": "straight", "aliStart": 110, "text": "MBT", "colour": "#9999ff", "aliEnd": 175, "start": 110, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 177, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 110, "scoreName": "E-value", "accession": "PF02820.16", "start": 110, "score": 7.899999999999999e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 175}}, {"startStyle": "straight", "end": 405, "endStyle": "straight", "aliStart": 297, "text": "SLED", "colour": "#9999ff", "aliEnd": 405, "start": 297, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 405, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF12140.6", "start": 297, "score": 1.3e-36, "identifier": "SLED domain", "type": "DBD", "aliEnd": 405}}, {"startStyle": "straight", "end": 573, "endStyle": "straight", "aliStart": 508, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 573, "start": 508, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 573, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 508, "scoreName": "E-value", "accession": "PF00536.28", "start": 508, "score": 4.3e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 573}}, {"startStyle": "straight", "end": 263, "endStyle": "straight", "aliStart": 210, "text": "RBR", "colour": "#9999ff", "aliEnd": 263, "start": 210, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 263, "description": NaN, "database": "PfamA", "aliStart": 210, "scoreName": "E-value", "accession": "PF17208.1", "start": 210, "score": 1.5e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 263}}, {"startStyle": "straight", "end": 573, "endStyle": "straight", "aliStart": 507, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 573, "start": 507, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 573, "description": NaN, "database": "PfamA", "aliStart": 507, "scoreName": "E-value", "accession": "PF07647.15", "start": 507, "score": 5.3e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 573}}, {"startStyle": "jagged", "end": 575, "endStyle": "straight", "aliStart": 505, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 573, "start": 492, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 575, "description": NaN, "database": "PfamA", "aliStart": 505, "scoreName": "E-value", "accession": "PF02198.14", "start": 492, "score": 0.00047999999999999996, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 573}}], "length": 578}

{"regions": [{"startStyle": "straight", "end": 83, "endStyle": "straight", "aliStart": 15, "text": "MBT", "colour": "#9999ff", "aliEnd": 82, "start": 15, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 83, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 15, "scoreName": "E-value", "accession": "PF02820.16", "start": 15, "score": 8.5e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 82}}, {"startStyle": "straight", "end": 191, "endStyle": "straight", "aliStart": 124, "text": "MBT", "colour": "#9999ff", "aliEnd": 189, "start": 124, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 191, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 124, "scoreName": "E-value", "accession": "PF02820.16", "start": 124, "score": 8.5e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 189}}, {"startStyle": "straight", "end": 419, "endStyle": "straight", "aliStart": 311, "text": "SLED", "colour": "#9999ff", "aliEnd": 419, "start": 311, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 419, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 311, "scoreName": "E-value", "accession": "PF12140.6", "start": 311, "score": 1.3e-36, "identifier": "SLED domain", "type": "DBD", "aliEnd": 419}}, {"startStyle": "straight", "end": 587, "endStyle": "straight", "aliStart": 522, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 587, "start": 522, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 587, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 522, "scoreName": "E-value", "accession": "PF00536.28", "start": 522, "score": 4.4e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 587}}, {"startStyle": "straight", "end": 277, "endStyle": "straight", "aliStart": 224, "text": "RBR", "colour": "#9999ff", "aliEnd": 277, "start": 224, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 277, "description": NaN, "database": "PfamA", "aliStart": 224, "scoreName": "E-value", "accession": "PF17208.1", "start": 224, "score": 1.5e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 277}}, {"startStyle": "straight", "end": 587, "endStyle": "straight", "aliStart": 521, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 587, "start": 521, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 587, "description": NaN, "database": "PfamA", "aliStart": 521, "scoreName": "E-value", "accession": "PF07647.15", "start": 521, "score": 5.0999999999999993e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 587}}, {"startStyle": "jagged", "end": 589, "endStyle": "straight", "aliStart": 519, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 587, "start": 506, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 589, "description": NaN, "database": "PfamA", "aliStart": 519, "scoreName": "E-value", "accession": "PF02198.14", "start": 506, "score": 0.00049, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 587}}], "length": 592}

{"regions": [{"startStyle": "straight", "end": 69, "endStyle": "straight", "aliStart": 1, "text": "MBT", "colour": "#9999ff", "aliEnd": 68, "start": 1, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 69, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF02820.16", "start": 1, "score": 8.599999999999998e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 68}}, {"startStyle": "straight", "end": 177, "endStyle": "straight", "aliStart": 110, "text": "MBT", "colour": "#9999ff", "aliEnd": 175, "start": 110, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 177, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 110, "scoreName": "E-value", "accession": "PF02820.16", "start": 110, "score": 8.599999999999998e-50, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 175}}, {"startStyle": "straight", "end": 405, "endStyle": "straight", "aliStart": 297, "text": "SLED", "colour": "#9999ff", "aliEnd": 405, "start": 297, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 405, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 297, "scoreName": "E-value", "accession": "PF12140.6", "start": 297, "score": 1.3e-36, "identifier": "SLED domain", "type": "DBD", "aliEnd": 405}}, {"startStyle": "straight", "end": 595, "endStyle": "straight", "aliStart": 530, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 595, "start": 530, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 595, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 530, "scoreName": "E-value", "accession": "PF00536.28", "start": 530, "score": 4.4e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 595}}, {"startStyle": "straight", "end": 263, "endStyle": "straight", "aliStart": 210, "text": "RBR", "colour": "#9999ff", "aliEnd": 263, "start": 210, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 263, "description": NaN, "database": "PfamA", "aliStart": 210, "scoreName": "E-value", "accession": "PF17208.1", "start": 210, "score": 1.5e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 263}}, {"startStyle": "straight", "end": 595, "endStyle": "straight", "aliStart": 529, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 595, "start": 529, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 595, "description": NaN, "database": "PfamA", "aliStart": 529, "scoreName": "E-value", "accession": "PF07647.15", "start": 529, "score": 5.7e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 595}}, {"startStyle": "jagged", "end": 597, "endStyle": "straight", "aliStart": 527, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 595, "start": 514, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 597, "description": NaN, "database": "PfamA", "aliStart": 527, "scoreName": "E-value", "accession": "PF02198.14", "start": 514, "score": 0.0005099999999999999, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 595}}], "length": 600}

{"regions": [{"startStyle": "straight", "end": 140, "endStyle": "straight", "aliStart": 72, "text": "MBT", "colour": "#9999ff", "aliEnd": 139, "start": 72, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 140, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 72, "scoreName": "E-value", "accession": "PF02820.16", "start": 72, "score": 1.1e-49, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 139}}, {"startStyle": "straight", "end": 248, "endStyle": "straight", "aliStart": 181, "text": "MBT", "colour": "#9999ff", "aliEnd": 246, "start": 181, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 248, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 181, "scoreName": "E-value", "accession": "PF02820.16", "start": 181, "score": 1.1e-49, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 246}}, {"startStyle": "straight", "end": 476, "endStyle": "straight", "aliStart": 368, "text": "SLED", "colour": "#9999ff", "aliEnd": 476, "start": 368, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 476, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 368, "scoreName": "E-value", "accession": "PF12140.6", "start": 368, "score": 1.3999999999999999e-36, "identifier": "SLED domain", "type": "DBD", "aliEnd": 476}}, {"startStyle": "straight", "end": 644, "endStyle": "straight", "aliStart": 579, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 644, "start": 579, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 644, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 579, "scoreName": "E-value", "accession": "PF00536.28", "start": 579, "score": 4.8e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 644}}, {"startStyle": "straight", "end": 334, "endStyle": "straight", "aliStart": 281, "text": "RBR", "colour": "#9999ff", "aliEnd": 334, "start": 281, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 334, "description": NaN, "database": "PfamA", "aliStart": 281, "scoreName": "E-value", "accession": "PF17208.1", "start": 281, "score": 1.8000000000000002e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 334}}, {"startStyle": "straight", "end": 644, "endStyle": "straight", "aliStart": 578, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 644, "start": 578, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 644, "description": NaN, "database": "PfamA", "aliStart": 578, "scoreName": "E-value", "accession": "PF07647.15", "start": 578, "score": 5.7e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 644}}, {"startStyle": "jagged", "end": 646, "endStyle": "straight", "aliStart": 576, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 644, "start": 563, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 646, "description": NaN, "database": "PfamA", "aliStart": 576, "scoreName": "E-value", "accession": "PF02198.14", "start": 563, "score": 0.00055, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 644}}], "length": 649}

{"regions": [{"startStyle": "straight", "end": 308, "endStyle": "straight", "aliStart": 200, "text": "SLED", "colour": "#9999ff", "aliEnd": 308, "start": 200, "href": "http://pfam.xfam.org/family/PF12140.6", "type": "pfama", "display": "true", "metadata": {"end": 308, "description": "The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb  group of proteins involved in epigenetic gene silencing [1].", "database": "PfamA", "aliStart": 200, "scoreName": "E-value", "accession": "PF12140.6", "start": 200, "score": 9.1e-37, "identifier": "SLED domain", "type": "DBD", "aliEnd": 308}}, {"startStyle": "straight", "end": 82, "endStyle": "straight", "aliStart": 15, "text": "MBT", "colour": "#9999ff", "aliEnd": 80, "start": 15, "href": "http://pfam.xfam.org/family/PF02820.16", "type": "pfama", "display": "true", "metadata": {"end": 82, "description": "The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.", "database": "PfamA", "aliStart": 15, "scoreName": "E-value", "accession": "PF02820.16", "start": 15, "score": 8.8e-21, "identifier": "mbt repeat", "type": "DBD", "aliEnd": 80}}, {"startStyle": "straight", "end": 476, "endStyle": "straight", "aliStart": 411, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 476, "start": 411, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 476, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 411, "scoreName": "E-value", "accession": "PF00536.28", "start": 411, "score": 3.2e-17, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 476}}, {"startStyle": "straight", "end": 166, "endStyle": "straight", "aliStart": 113, "text": "RBR", "colour": "#9999ff", "aliEnd": 166, "start": 113, "href": "http://pfam.xfam.org/family/PF17208.1", "type": "pfama", "display": "true", "metadata": {"end": 166, "description": NaN, "database": "PfamA", "aliStart": 113, "scoreName": "E-value", "accession": "PF17208.1", "start": 113, "score": 1.3e-13, "identifier": "RNA binding Region", "type": "DBD", "aliEnd": 166}}, {"startStyle": "straight", "end": 476, "endStyle": "straight", "aliStart": 410, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 476, "start": 410, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 476, "description": NaN, "database": "PfamA", "aliStart": 410, "scoreName": "E-value", "accession": "PF07647.15", "start": 410, "score": 3.5e-08, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 476}}, {"startStyle": "jagged", "end": 478, "endStyle": "straight", "aliStart": 408, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 476, "start": 395, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 478, "description": NaN, "database": "PfamA", "aliStart": 408, "scoreName": "E-value", "accession": "PF02198.14", "start": 395, "score": 0.00037, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 476}}], "length": 481}

{"regions": [{"startStyle": "straight", "end": 137, "endStyle": "straight", "aliStart": 72, "text": "SAM_1", "colour": "#9999ff", "aliEnd": 137, "start": 72, "href": "http://pfam.xfam.org/family/PF00536.28", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": "It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.", "database": "PfamA", "aliStart": 72, "scoreName": "E-value", "accession": "PF00536.28", "start": 72, "score": 4.2e-18, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 137}}, {"startStyle": "straight", "end": 137, "endStyle": "straight", "aliStart": 71, "text": "SAM_2", "colour": "#9999ff", "aliEnd": 137, "start": 71, "href": "http://pfam.xfam.org/family/PF07647.15", "type": "pfama", "display": "true", "metadata": {"end": 137, "description": NaN, "database": "PfamA", "aliStart": 71, "scoreName": "E-value", "accession": "PF07647.15", "start": 71, "score": 6.6e-09, "identifier": "SAM domain (Sterile alpha motif)", "type": "DBD", "aliEnd": 137}}, {"startStyle": "jagged", "end": 140, "endStyle": "straight", "aliStart": 69, "text": "SAM_PNT", "colour": "#9999ff", "aliEnd": 137, "start": 56, "href": "http://pfam.xfam.org/family/PF02198.14", "type": "pfama", "display": "true", "metadata": {"end": 140, "description": NaN, "database": "PfamA", "aliStart": 69, "scoreName": "E-value", "accession": "PF02198.14", "start": 56, "score": 4.5e-05, "identifier": "Sterile alpha motif (SAM)/Pointed domain", "type": "DBD", "aliEnd": 137}}], "length": 142}

TF Info Page for SCMH1 (Unknown)