The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif		Has a SLED domain (IPR021987). (PMID: 24727478) claims, based on NMR, that SLED is a sequence-specific DBD with relatively high specificity

Description

Description:

sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19003];Polycomb protein SCMH1

Entrez Summary

Ensembl ID:

ENSG00000010803

External Link:

CisBP

Interpro

IPR001660; IPR004092; IPR013761; IPR021129; IPR021987;

Protein Domain:

ENSP00000318094

Protein Domain:

ENSP00000354656

Protein Domain:

ENSP00000354996

Protein Domain:

ENSP00000361676

Protein Domain:

ENSP00000361677

Protein Domain:

ENSP00000361678

Protein Domain:

ENSP00000380356

Protein Domain:

ENSP00000337352

Protein Domain:

ENSP00000380359

Protein Domain:

ENSP00000403974

Protein Domain:

ENSP00000479881

Domain:

Protein: ENSP00000318094	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000354656	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000354996	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361676	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361677	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000361678	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000380356	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000337352	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000380359	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000403974	DBD: Other	Other: MBT, RBR, SAM_1, SAM_2, SAM_PNT, SLED
Protein: ENSP00000479881	DBD: Other	Other: SAM_1, SAM_2, SAM_PNT

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene Candidate__Other_ PMIDS:10653359
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	No
CisBP considers it as a TF?	No
TFclass considers it as a TF?	No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:10524249
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for SCMH1 (Unknown)

Conclusion

Description

Previous Annotations

DNA-Binding

Published Motif Data

Structure

Experimental History

External Contribution