Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721)
Description
Description:
ETS variant 7 [Source:HGNC Symbol;Acc:HGNC:18160]
Entrez Summary
The protein encoded by this gene belongs to the ETS family of
transcription factors, which is a large group of evolutionarily conserved
transcriptional regulators that play an important role in a variety of
cellular processes throughout development and differentiation, and are
involved in oncogenesis as well. This protein is predominantly expressed in
hematopoietic tissues. Several alternatively spliced transcript variants
encoding different isoforms have been described for this gene
(PMID:11108721).[provided by RefSeq, May 2011]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:11108721
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF