TF Info Page for ETV7 (Ets)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721)


Description: ETS variant 7 [Source:HGNC Symbol;Acc:HGNC:18160]
Entrez Summary The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011]
Ensembl ID: ENSG00000010030
External Link: CisBP
Interpro IPR000418; IPR003118; IPR013761; ;
Protein Domain: ENSP00000342260
Protein Domain: ENSP00000341843
Protein Domain: ENSP00000362842
Protein Domain: ENSP00000362843
Protein Domain: ENSP00000481885
Protein Domain: ENSP00000484485
Protein Domain: ENSP00000486712
Protein Domain: ENSP00000440592
Protein: ENSP00000342260DBD: ETSOther: SAM_PNT
Protein: ENSP00000341843DBD: ETSOther: SAM_PNT
Protein: ENSP00000362842DBD: ETSOther: SAM_PNT
Protein: ENSP00000362843DBD: ETSOther:
Protein: ENSP00000481885DBD: ETSOther:
Protein: ENSP00000484485DBD: ETSOther: SAM_PNT
Protein: ENSP00000486712DBD: ETSOther:
Protein: ENSP00000440592DBD: ETSOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:11108721
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
PBMWei10Inferred - Etv6 (82% AA Identity, Mus musculus)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution