get eID ENSG00000008197 else done selects

TF Info Page for TFAP2D (AP-2)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Binds the same GCCTGAGGC sequence as the other AP-2s (PMID: 24789576)

Description

Description: transcription factor AP-2 delta [Source:HGNC Symbol;Acc:HGNC:15581]
Entrez Summary TBA
Ensembl ID: ENSG00000008197
External Link: T004844_1.02
Interpro IPR013854; ;
Protein Domain:
Protein: ENSP00000008391DBD: AP-2Other:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
MiscHocoMocoDirect
PBMBadis09Inferred - Tfap2a (77% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - TFAP2A (76% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TFAP2A (76% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TFAP2E (76% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TFAP2E (76% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TFAP2E (76% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TFAP2E (76% AA Identity, Homo sapiens)
PBMBadis09Inferred - Tfap2e (76% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - TFAP2A (76% AA Identity, Homo sapiens)
SELEXJASPARInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2A (76% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TFAP2A (76% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TFAP2B (74% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TFAP2B (74% AA Identity, Homo sapiens)
PBMBadis09Inferred - Tfap2b (74% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - TFAP2B (74% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TFAP2B (74% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TFAP2C (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TFAP2C (71% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - TFAP2C (71% AA Identity, Homo sapiens)
SELEXJASPARInferred - TFAP2C (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2C (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2C (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2C (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - TFAP2C (71% AA Identity, Homo sapiens)
MiscHocoMocoInferred - TFAP2C (71% AA Identity, Homo sapiens)
MiscHOMERInferred - TFAP2C (71% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution