TF Info Page for GTF2IRD1 (GTF2I-like)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious. V$BEN_02 motif has partial similarity to a shift-experiment sequence (PMID:14645227), which shows DNA-binding and evidence of transcriptional regulation by knockdown experiments |
Description
| Description: | GTF2I repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:4661] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000006704 | |
| External Link: | ||
| Interpro | IPR004212; IPR016659; | |
| Protein Domain: | ||
| Protein: ENSP00000265755 | DBD: GTF2I | Other: |
| Protein: ENSP00000408477 | DBD: GTF2I | Other: |
| Protein: ENSP00000397566 | DBD: GTF2I | Other: |
| Protein: ENSP00000418383 | DBD: GTF2I | Other: |
| Protein: ENSP00000417909 | DBD: GTF2I | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:14645227 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity NAS - PMID:10575229 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity NAS - PMID:9774679 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |