TF Info Page for ETV1 (Ets)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: ETS variant 1 [Source:HGNC Symbol;Acc:HGNC:3490]
Entrez Summary This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5 '-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Ensembl ID: ENSG00000006468
External Link: CisBP
Interpro IPR000418; IPR006715;
Protein Domain: ENSP00000384138
Protein Domain: ENSP00000385686
Protein Domain: ENSP00000385381
Protein Domain: ENSP00000405327
Protein Domain: ENSP00000393078
Protein Domain: ENSP00000382293
Protein Domain: ENSP00000411626
Domain:
Protein: ENSP00000384138DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000385686DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000385381DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000405327DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000393078DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000382293DBD: ETSOther: ETS_PEA3_N
Protein: ENSP00000411626DBD: ETSOther: ETS_PEA3_N

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:12750007
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12750007
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:7700648
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHOMERDirect
PBMWei10Inferred - Etv1 (100% AA Identity, Mus musculus)
PBMWei10Inferred - Etv1 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV4 (96% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv4 (96% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ETV5 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (96% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ETV5 (96% AA Identity, Homo sapiens)
PBMWei10Inferred - Etv5 (96% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ETV4 (96% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ETV4 (96% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV4 (96% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ETV5 (96% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Ets96B (87% AA Identity, Drosophila melanogaster)
PBMWei10Inferred - Ets1 (65% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - pnt (65% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - ETS1B_CHICK (65% AA Identity, Gallus gallus)
PBMWei10Inferred - Elk4 (61% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ELK4 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK4 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK4 (60% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - ELK4 (60% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - ELK4 (60% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - ELK4 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (60% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK4 (60% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK4 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (59% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK1 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK1 (59% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk1 (59% AA Identity, Mus musculus)
SELEXJASPARInferred - ELK1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ELK1 (59% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ELK1 (59% AA Identity, Homo sapiens)
MiscHOMERInferred - ELK1 (59% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (58% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - ERG (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ERG (58% AA Identity, Homo sapiens)
PBMWei10Inferred - Erg (58% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - Ets21C (58% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Ets21C (58% AA Identity, Drosophila melanogaster)
SELEXJASPARInferred - ERG (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (58% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ERG (58% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ERG (58% AA Identity, Homo sapiens)
MiscHOMERInferred - ERG (58% AA Identity, Homo sapiens)
PBMZoo_01Inferred - elk4 (57% AA Identity, Tetraodon nigroviridis)
HT-SELEXNitta2015Inferred - Ets65A (57% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - FEV (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FEV (57% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FEV (57% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ELK3 (56% AA Identity, Homo sapiens)
PBMWei10Inferred - Elk3 (56% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - GABPA (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GABPA (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GABPA (56% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gabpa (56% AA Identity, Mus musculus)
PBMWei10Inferred - Gabpa (56% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ELK3 (56% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (56% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (56% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (56% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (56% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GABPA (56% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gabpa (56% AA Identity, Mus musculus)
MiscHocoMocoInferred - ELK3 (56% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GABPA (56% AA Identity, Homo sapiens)
MiscHOMERInferred - GABPA (56% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FLI1 (55% AA Identity, Homo sapiens)
PBMWei10Inferred - Fli1 (55% AA Identity, Mus musculus)
SELEXJASPARInferred - FLI1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (55% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FLI1 (55% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FLI1 (55% AA Identity, Homo sapiens)
MiscHOMERInferred - Fli1 (55% AA Identity, Mus musculus)

Structure

Structure PDB 4BNC

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution