TF Info Page for SOX8 (HMG/Sox)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: SRY-box 8 [Source:HGNC Symbol;Acc:HGNC:11203]
Entrez Summary This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]
Ensembl ID: ENSG00000005513
External Link: CisBP
Interpro IPR009071; IPR022151;
Protein Domain: ENSP00000293894
Domain:
Protein: ENSP00000293894DBD: HMGOther: Sox_N

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding
TF PPI_
PMIDS:12732652
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMBadis09Inferred - Sox8 (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - SOX9 (98% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SOX9 (98% AA Identity, Homo sapiens)
SELEXJASPARInferred - SOX9 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX9 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX9 (98% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX9 (98% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SOX9 (98% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - SOX10 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - SOX10 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - SOX10 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SOX10 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SOX10 (94% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Sox10 (94% AA Identity, Mus musculus)
COMPILEDJASPARInferred - SOX10 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX10 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX10 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - SOX10 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - SOX10 (94% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution