The Human Transcription Factors

DBD Alignment (Click to open/enlarge)

Click to download Alignment and Tree

No Structure and Description available

Ensembl ID	HGNC symbol	DBD Family	Is TF?	TF Assessment	Binding Mode	Motif Status	Notes	Comments
	BAZ2B	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif	Has a putative AT-hook
	MBD2	MBD	Yes	Known motif	3 Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook
	MBD3	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif		The MBD domain of MBD3 is thought to be primarily responsible for interaction with HDAC1 and MTA2, members of the NuRD complex (PMID: 12124384). More recently, studies have shown that it retains the ability to bind methylated CpG sites in vitro (PMID: 24307175) with lower affinity than other MBD proteins (e.g., MBD2), but does not distinguish between hydroxymethylated and unmethylated sites. Coupled with in vivo ChIP experiments, it appears that MBD3 binds unmethylated CpG sites in vivo after be
	MBD4	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif
	MBD6	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif		Has not been tested on PBM or HT-SELEX. Some evidence exists showing that it does not bind methylated DNA (PMID: 20700456), and the MBD domain instead facilitates protein interactions (PMID: 24634419).
	PIN1	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif
	SETDB1	MBD	Yes	Known motif	3 Low specificity DNA-binding protein	In vivo/Misc source	Only known motifs are from Transfac or HocoMoco - origin is uncertain	Transfac motif is dubious.
	SETDB2	MBD	Yes	Likely to be sequence specific TF	3 Low specificity DNA-binding protein	No motif