Collection of 11 putative E2F human TFs out of 11 considered proteins

DBD Alignment (Click to open/enlarge)


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Description
There are 11 TFs with E2F domains that can be divided into two subclasses, E2F and DP domains. Six of the TFs, E2F[1-6]contain just an E2F domain, three DP-proteins, TFDP 1 to 3, contain just a DP domain and two of them (E2F7 and E2F8) contain two E2F-like domains. 		Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
E2F1 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
E2F2 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Can also bind as a heterodimer with DP1 (PMID: 16360038)
E2F3 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Binds preferentially with DP proteins in vivo
E2F4 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
E2F5 E2F Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain Also heterodimerzes with DP2 (PMID: 7760804)
E2F6 E2F Yes Known motif 1 Monomer or homomultimer In vivo/Misc source
E2F7 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
E2F8 E2F Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
TFDP1 E2F Yes Known motif 2 Obligate heteromer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
TFDP2 E2F Yes Inferred motif 2 Obligate heteromer In vivo/Misc source
TFDP3 E2F Yes Inferred motif 2 Obligate heteromer In vivo/Misc source Interacts with E2F1; E2F2; E2F3; E2F4 and E2F5 (PMID: 17062573).