Collection of 2 putative CxxC; AT hook human TFs out of 2 considered proteins

No Alignment available for CxxC;AThook
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
KMT2A CxxC; AT hook Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Contains 3 AT-hook domain, a CXXC domain, and a possible C2H2 domain.
KMT2B CxxC; AT hook Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Structural evidence shows direct DNA-binding (PDB:4PZI) and KMT2B appears to make specific contacts with methylated DNA.