TF Info Page for PPARA (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Description
| Description: | peroxisome proliferator activated receptor alpha [Source:HGNC Symbol;Acc:HGNC:9232] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000186951 | |
| External Link: | T132781_1.02 | |
| Interpro | IPR000536; IPR001628; IPR001723; IPR003074; IPR003076; IPR008946; | |
| Protein Domain: | ||
| Protein: ENSP00000385246 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000385523 | DBD: Nuclear Hormone Receptor | Other: Hormone_recep |
| Protein: ENSP00000397291 | DBD: Nuclear Hormone Receptor | Other: |
| Protein: ENSP00000414752 | DBD: Nuclear Hormone Receptor | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:1537328 8123021 8386511 12847522 9748239 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:9748239 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:9748239 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:19955185 | ISS - GO_REF:0000024 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:12955147, PMID:19955185 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |