This file contains the official list of human TF motifs from Lambert et al (PMID:29425488), along with associated information. You probably obtained it from the website accompanying that study (http://humantfs.ccbr.utoronto.ca/download.php). Motifs were largely obtained from the Cis-BP web server (http://cisbp.ccbr.utoronto.ca/). Both directly experimentally established motifs ("Direct") and motifs inferred from related TFs ("Inferred") are included. Details on how the inferences are performed are available in Weirauch et al (PMID:25215497). At the time of publication of the human TF review, data were obtained from a new build of Cis-BP that was still under development (build 1.94d). This build will eventually form the basis for Cis-BP public build 2.0, along with the addition of further motifs. This file thus currently represents the latest list of available motifs, but it will become obsolete with future builds of Cis-BP (especially for builds after 2.0). Questions and comments can be directed to Matt Weirauch (Matthew.Weirauch@cchmc.org). Database fields: Ensembl ID - Official Ensembl gene ID. HGNC symbol - Official gene name. Motif evidence - Was the motif directly determined experimentally, or inferred from experimental data from a related TF? For inferred motifs, the name and species of the TF from which the motif was inferred are listed, along with the percent amino acid identity of the protein's DNA binding domain. See Weirauch et al for details on the motif inferences. Motif ID - Motif ID from the original data source. Motif type - Type of data that produced the motif. This can be experiment type (e.g., PBM or HT-SELEX) or another database (e.g., JASPAR or Transfac). Motif source - Source of the data. Most are in the format of Author/Year. CIS-BP ID - ID from the Cis-BP motif database, build 1.94d. Best Motif(s)? (Figure 2A) - Was the motif chosen as the "best motif" for the TF (see Lambert et al for details).