Collection of 4 putative mTERF human TFs out of 5 considered proteins

DBD Alignment (Click to open/enlarge)


Click to download Alignment and Tree
Description
 Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
MTERF1 mTERF Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain The structure (PDB: 3MVA) shows a large protein DNA-interaction interface.
MTERF2 mTERF Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif
MTERF3 mTERF Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif Crystral structure available (PMID: 20430012)
MTERF4 mTERF Yes Likely to be sequence specific TF 1 Monomer or homomultimer No motif MTERF4 can bind RNA (PMID: 22949673), but likely to also bind DNA like other mTERF family members.
NEB mTERF No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Gene Cards/GO indicates that NEB is not present in the nucleus; and it appears to be an actin binding protein highly expressed in muscle.