Collection of 49 putative Forkhead human TFs out of 50 considered proteins

DBD Alignment (Click to open/enlarge)


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Description
Forkhead box (FOX) is a fairly large structural class with approximately 50 TFs. Interestingly, the structure of these TFs, a winged helix-turn-helix protein fold, is similar to the H1 linker histones suggesting that these proteins share a common origin. This similarity is also reflected in the function of these TFs, as like the linker histones, many of these TFs can bind to DNA that is packed into a nucleosome. 		Structure
Ensembl ID HGNC symbol DBD Family Is TF? TF Assessment Binding Mode Motif Status Notes Comments
FOXA1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXA2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXA3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXB1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXB2 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXC1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXC2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXD1 Forkhead Yes Known motif 1 Monomer or homomultimer 100 perc ID - in vitro
FOXD2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXD3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXD4 Forkhead Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
FOXD4L1 Forkhead Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
FOXD4L2 Forkhead No Unlikely to be sequence specific TF 4 Not a DNA binding protein No motif Only known motifs are from Transfac or HocoMoco - origin is uncertain This ENSEMBL ID has been retired.
FOXD4L3 Forkhead Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
FOXD4L4 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
FOXD4L5 Forkhead Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
FOXD4L6 Forkhead Yes Inferred motif 1 Monomer or homomultimer In vivo/Misc source
FOXE1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXE3 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXF1 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
FOXF2 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source
FOXG1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXH1 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Full length protein did not yield an HT-SELEX motif
FOXI1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXI2 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXI3 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXJ1 Forkhead Yes Known motif 1 Monomer or homomultimer 100 perc ID - in vitro
FOXJ2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXJ3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXK1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXK2 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXL1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXL2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXM1 Forkhead Yes Known motif 1 Monomer or homomultimer 100 perc ID - in vitro
FOXN1 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
FOXN2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXN3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXN4 Forkhead Yes Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain
FOXO1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXO3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXO4 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXO6 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXP1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro Has a putative AT-hook
FOXP2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXP3 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXP4 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro
FOXQ1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXR1 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXR2 Forkhead Yes Known motif 1 Monomer or homomultimer High-throughput in vitro
FOXS1 Forkhead Yes Inferred motif 1 Monomer or homomultimer High-throughput in vitro